The Science Behind Ozonated Magnesium Oxide: Clinically Proven for Digestive Health
Backed by clinical research, Ozonated Magnesium Oxide is the breakthrough digestive solution that relieves constipation, detoxifies the gut, and supports long-term gut health—without harsh laxatives
Read the Full Study
Backed by Clinical Research & Designed for Better Gut Health
For centuries, magnesium compounds have been used to support digestion, with magnesium oxide (MgO) being one of the most effective. Research from the Nutrients Journal (PMC Study) confirms that magnesium oxide is a safe, well-tolerated laxative that supports bowel regularity, detoxification, and gut health—without harsh side effects.
Unlike traditional laxatives that cause dependency, magnesium oxide works by drawing water into the intestines, softening stool naturally. This means no cramping, no bloating, and no harsh urgency—just smooth, regular digestion.
What the Science Says
- Proven to Relieve Occasional Constipation – Studies show magnesium oxide enhances water retention in the gut, leading to softer stools and easier elimination.
- Detoxifies the Digestive System – Helps remove waste and toxins while supporting a healthy gut microbiome.
- Safe for Long-Term Use – Unlike stimulant laxatives, it doesn’t cause dependency or disrupt gut bacteria balance.
- Supports Overall Health – Linked to better hydration, muscle recovery, and improved sleep.
Ozonated Magnesium Oxide: A Next-Level Digestive Solution
How Let Loose Enhances the Power of Magnesium Oxide
Most magnesium oxide supplements are basic mineral compounds, but Let Loose uses an ozonated form for superior gut-cleansing effects. Ozonation is a specialized process that infuses magnesium oxide with oxygen to create a more bioavailable, highly effective digestive aid.
How Ozonated Magnesium Oxide Works
1
Increases Oxygen
Flow to the Gut
The ozonated formula helps oxidize and break down waste, promoting deep colon cleansing.
2
Supports Gentle,
Overnight Detox
Unlike stimulant laxatives, ozonated magnesium works without cramping or bloating.
3
Promotes Healthy
Bacteria Balance
By increasing oxygen in the gut, it helps support a thriving microbiome.
How Let Loose Uses This Research for Maximum Benefits
While most laxatives rely on stimulants that can disrupt digestion and cause urgency, Let Loose takes a different approach. Our oxygenated magnesium oxide formula is:
- ✔️ Doctor-Recommended – Backed by real science & GI experts.
- ✔️ Fast-Acting & Gentle – Works overnight without discomfort.
- ✔️ All-Natural, No Harsh Laxatives – No Senna, no dependency, just smooth relief.
Hyperice
Daily Capsule For Smooth, Sress-Free Poops
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Experience the Science of Better Digestion
Let Loose is more than just another supplement—it’s backed by science, trusted by experts, and formulated for real digestive relief. No harsh chemicals. No dependency. Just better gut health, every day.
Final Thought: Backed by Research, Trusted by Experts
Dr. James H Tabibian, MD, PhD, Gastroenterologist, Let Loose Medical Advisor
“It’s uncomfortable, frustrating, and can disrupt a person’s lifestyle. That’s why I was excited to join the team behind Let Loose—a science-backed, natural supplement designed to tackle constipation head-on.”
– Dr. James H Tabibian, MD, PhD, Gastroenterologist
This scientific breakthrough in digestive health is transforming the way people experience gut relief. By merging clinical research with the power of oxygenated magnesium oxide, Let Loose delivers a modern solution to an age-old problem—without the side effects of harsh laxatives.
Hyperice
Daily Capsule For Smooth, Sress-Free Poops
$54
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How Let Loose TrioBiotic Works
Your gut is home to trillions of microbes and a delicate barrier that lines your intestines. When this ecosystem is out of balance, digestion may suffer - manifesting as irregularity, bloating, gas, or slow transit.
TrioBiotic supports gut health with a three-pronged approach:
- Probiotics – beneficial live microbes that survive digestion and reach the gut.
- Postbiotics – non-live microbial components that still trigger beneficial responses.
- Prebiotics & Resistant Starch – fibers that selectively feed good microbes and promote beneficial by-products (short-chain fatty acids) that nourish your gut lining and beyond.
Together, these ingredients promote:
- A stronger gut barrier (meaning fewer leaks & less inflammation)
- A healthier microbiome (more good bacteria, fewer “bad” ones)
- Better digestive regularity and comfort
- Support for metabolic health, immunity, and nutrient absorption
Bacillus coagulans (2 Billion CFU)
-
Mechanism highlights:
- Spore-forming resilience → survives stomach acid and bile to reach intestines. ScienceDirect+1
- Produces digestive enzymes and short-chain fatty acids → supports digestion and gut lining health. BioMed Central
- Modulates immune function and microbiota balance. ScienceDirect+1
-
Clinical benefits shown in human trials:
- Improves IBS symptoms: reduced abdominal pain & increased complete spontaneous bowel movements. Nature
- Safe at 2 × 10⁹ CFU/day in adults with diarrhea-predominant IBS. BioMed Central
-
Additional demonstrated benefits:
- Better stool regularity + improved stool consistency
- Reduction in occasional bloating and gas
- Enhanced nutrient absorption and digestive efficiency
- Support for immune and gut-brain axis pathways
Bacillus subtilis (2 Billion CFU)
-
Mechanism highlights:
- Spore-forming bacterium supporting a diverse microbiome and producing antimicrobial compounds inhibiting pathogens. Lippincott Journals
- Supports intestinal barrier integrity and healthy immune signalling.
-
Benefits for your site:
- Helps rebalance gut flora and crowd out less beneficial bacteria
- Strengthens gut lining to reduce “gut leakiness”
- May reduce occasional digestive inflammation, gas, & discomfort
- Supports immune resilience from the gut
Akkermansia muciniphila (Heat-Killed AH-39)
-
Mechanism highlights:
- Resides in the mucous layer of the gut, interacting with intestinal lining and influencing metabolism. [Gut+1]
- Even pasteurized (heat-killed) form shows metabolic and barrier benefits. [Nature+1]
-
Clinical insights:
- In overweight/insulin-resistant humans, supplementation correlated with improvements in insulin sensitivity, fat mass, and inflammation markers. [Nature+1]
-
Benefits for your site:
- Strengthens gut barrier & reduces intestinal permeability
- Supports healthy metabolism (weight, insulin, lipid balance)
- Promotes microbiome diversity and long-term digestive resilience
Xylooligosaccharides (XOS)
-
Mechanism highlights:
- Specific prebiotic fiber that selectively increases beneficial bacteria like Bifidobacteria. [PMC+1]
- Supports production of short-chain fatty acids and reduces gut pH → beneficial environment for gut health. [Cambridge University Press & Assessment]
-
Benefits for your site:
- Improves stool frequency & consistency (including relief from functional constipation)
- Supports smoother digestion & reduction in occasional bloating
- Helps maintain a resilient gut environment that supports metabolism and immunity
Galactooligosaccharides (GOS)
-
Mechanism highlights:
- Prebiotic fiber broadly supporting Bifidobacteria and Lactobacilli, especially in older adults. [Cambridge University Press & Assessment]
- Associated with improved mineral absorption and immune signalling.
-
Benefits for your site:
- Supports daily regularity and softer, more comfortable bowel movements
- Nourishes good bacteria and supports overall gut microbiome balance
- Helps support mineral absorption (calcium, magnesium) and immune health
Green Banana Powder (Resistant Starch)
-
Mechanism highlights:
- High in resistant starch (RS) which reaches the colon to fuel beneficial microbes and produce short-chain fatty acids (especially butyrate). [PMC+1]
- Supports gut barrier restoration and microbial balance. [PMC+1]
-
Benefits for your site:
- Promotes stool form, regularity, and digestive comfort
- Supports blood sugar balance and healthy metabolism
- Helps soothe and strengthen the intestinal lining
- Adds a natural prebiotic fiber that supports your microbiome’s long-term health
Hyperice
Advanced Daily TrioBiotic: Complete Pre + Pro + Postbiotic Support
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Summary
TrioBiotic from Let Loose is built on multiple layers of science:
- Two robust spore-forming probiotics (B. coagulans + B. subtilis) that survive the digestive tract and reach your intestines alive.
- A next-generation postbiotic (A. muciniphila heat-killed) with demonstrated benefits for gut lining & metabolism.
- Two potent prebiotic fibers (XOS + GOS) and a resistant starch source (green banana) to feed and empower your microbiome.
Together, this formula helps deliver smoother digestion, better regularity, a stronger gut barrier, a more resilient microbiome, and supportive metabolic & immune benefits – tailored for the young, active, health-conscious consumer.
Read the Papers
- Depommier C, et al. Supplementation with Akkermansia muciniphila in overweight/obese insulin-resistant volunteers: a randomized, double-blind, placebo-controlled pilot study. Nature Medicine 2019. [Nature]
- Madempudi R.S., et al. The effect of Bacillus coagulans Unique IS2 in adults with IBS: randomized double-blind study. Scientific Reports 2019. [Nature]
- Yan J., et al. Akkermansia muciniphila: is it the Holy Grail for ameliorating metabolic disorders? Gut Microbes 2021. [PMC]
- Yi W., et al. Xylo-oligosaccharides improve functional constipation by modulating the gut microbiota. Frontiers in Nutrition 2023. [PMC]
- Baek G.H., et al. Prebiotic potential of green banana flour: impact on gut microbiota composition in mice. Frontiers in Nutrition 2023. [Frontiers]
- Walton G.E., et al. A randomised crossover study investigating the effects of galacto-oligosaccharides on the faecal microbiota in men and women over 50 years of age. British Journal of Nutrition 2012. [Cambridge University Press & Assessment]
Legal/Scientific Disclaimer
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. Please consult your healthcare provider before beginning any new supplement regimen, especially if you are pregnant, nursing, taking medications, or have a medical condition.